Infant Brain Structures, Executive Function, and Attention Deficit/Hyperactivity Problems at Preschool Age. A Prospective Study

Autor/inn/en	Ghassabian, Akhgar; Herba, Catherine M.; Roza, Sabine J.; Govaert, Paul; Schenk, Jacqueline J.; Jaddoe, Vincent W.; Hofman, Albert; White, Tonya; Verhulst, Frank C.; Tiemeier, Henning
Titel	Infant Brain Structures, Executive Function, and Attention Deficit/Hyperactivity Problems at Preschool Age. A Prospective Study
Quelle	In: Journal of Child Psychology and Psychiatry, 54 (2013) 1, S.96-104 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2012.02590.x
Schlagwörter	Brain Hemisphere Functions; Attention Deficit Hyperactivity Disorder; Child Behavior; Neurology; Inhibition; Executive Function; Infants; Check Lists; Short Term Memory; Diagnostic Tests; Correlation; Young Children; Cognitive Processes; Emotional Response; Planning; Age Differences; Predictor Variables; Foreign Countries; Netherlands; Child Behavior Checklist + Suchen Sie Ihr Suchwort? Neurologie; Hemmung; Infant; Toddler; Toddlers; Kleinkind; Checkliste; Kurzzeitgedächtnis; Diagnostic test; Diagnostischer Test; Korrelation; Frühe Kindheit; Cognitive process; Kognitiver Prozess; Emotionales Verhalten; Ablaufplanung; Planungsprozess; Age; Difference; Age difference; Altersunterschied; Prädiktor; Ausland; Niederlande
Abstract	Background: Neuroimaging findings have provided evidence for a relation between variations in brain structures and Attention Deficit/Hyperactivity Disorder (ADHD). However, longitudinal neuroimaging studies are typically confined to children who have already been diagnosed with ADHD. In a population-based study, we aimed to characterize the prospective association between brain structures measured during infancy and executive function and attention deficit/hyperactivity problems assessed at preschool age. Methods: In the Generation R Study, the corpus callosum length, the gangliothalamic ovoid diameter (encompassing the basal ganglia and thalamus), and the ventricular volume were measured in 784 6-week-old children using cranial postnatal ultrasounds. Parents rated executive functioning at 4 years using the Behavior Rating Inventory of Executive Function-Preschool Version in five dimensions: inhibition, shifting, emotional control, working memory, and planning/organizing. Attention Deficit/Hyperactivity Problems were assessed at ages 3 and 5 years using the Child Behavior Checklist. Results: A smaller corpus callosum length during infancy was associated with greater deficits in executive functioning at 4 years. This was accounted for by higher problem scores on inhibition and emotional control. The corpus callosum length during infancy did not predict Attention Deficit/Hyperactivity Problem at 3 and 5 years, when controlling for the confounders. We did not find any relation between gangliothalamic ovoid diameter and executive function or Attention Deficit/Hyperactivity Problem. Conclusions: Variations in brain structures detectible in infants predicted subtle impairments in inhibition and emotional control. However, in this population-based study, we could not demonstrate that early structural brain variations precede symptoms of ADHD. (Contains 3 tables and 1 figure.) (As Provided).
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Update	2017/4/10