Neuroanatomical Correlates of Heterotypic Comorbidity in Externalizing Male Adolescents

Autor/inn/en	Sauder, Colin L.; Beauchaine, Theodore P.; Gatzke-Kopp, Lisa M.; Shannon, Katherine E.; Aylward, Elizabeth
Titel	Neuroanatomical Correlates of Heterotypic Comorbidity in Externalizing Male Adolescents
Quelle	In: Journal of Clinical Child and Adolescent Psychology, 41 (2012) 3, S.346-352 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1537-4416
DOI	10.1080/15374416.2012.658612
Schlagwörter	Psychopathology; Behavior Disorders; Attention Deficit Hyperactivity Disorder; Adolescents; Neurology; Anxiety; Males; Correlation; Symptoms (Individual Disorders); Prediction; Brain; Comparative Analysis + Suchen Sie Ihr Suchwort? Psychopathologie; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Neurologie; Angst; Male; Männliches Geschlecht; Korrelation; Psychiatrische Symptomatik; Vorhersage; Gehirn
Abstract	Children and adolescents with externalizing behavior disorders including attention-deficit/hyperactivity disorder (ADHD) and conduct disorder (CD) often present with symptoms of comorbid internalizing psychopathology. However, few studies have examined central nervous system correlates of such comorbidity. We evaluated interactions between externalizing and internalizing symptoms in predicting mesolimbic, septo-hippocampal, and anterior cingulate volumes among 12- to 16-year-old boys with either ADHD, ADHD and CD, or no psychiatric condition (n = 35). These regions were chosen given established links to trait impulsivity, trait anxiety, and behavior regulation, respectively. Collapsed across groups, Externalizing x Internalizing symptom interactions accounted for individual differences in gray matter densities in each region. Externalizing youth with comorbid internalizing symptoms showed smaller reductions in gray matter than individuals with externalizing psychopathology alone. These results suggest that internalizing symptoms are associated with less severe structural compromises in brain regions subserving motivation and behavior regulation among externalizing boys. (Contains 2 tables, 1 figure and 1 footnote.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10