Error-Related Negativity and Tic History in Pediatric Obsessive-Compulsive Disorder

Autor/inn/en	Hanna, Gregory L.; Carrasco, Melisa; Harbin, Shannon M.; Nienhuis, Jenna K.; LaRosa, Christina E.; Chen, Poyu; Fitzgerald, Kate D.; Gehring, William J.
Titel	Error-Related Negativity and Tic History in Pediatric Obsessive-Compulsive Disorder
Quelle	In: Journal of the American Academy of Child & Adolescent Psychiatry, 51 (2012) 9, S.902-910 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0890-8567
DOI	10.1016/j.jaac.2012.06.019
Schlagwörter	Evidence; Anxiety Disorders; Patients; Correlation; Brain Hemisphere Functions; Diagnostic Tests; Responses; Comorbidity; Comparative Analysis; Task Analysis; Clinical Diagnosis; Youth; Control Groups; Symptoms (Individual Disorders); Severity (of Disability); Error Patterns; Measurement; Neurological Impairments + Suchen Sie Ihr Suchwort? Evidenz; Patient; Korrelation; Diagnostic test; Diagnostischer Test; Aufgabenanalyse; Jugend; Jugendlicher; Jugendalter; Psychiatrische Symptomatik; Schweregrad; Fehlertyp; Messverfahren; Neurodegenerative Erkrankung
Abstract	Objective: The error-related negativity (ERN) is a negative deflection in the event-related potential after an incorrect response, which is often increased in patients with obsessive-compulsive disorder (OCD). However, the relation of the ERN to comorbid tic disorders has not been examined in patients with OCD. This study compared ERN amplitudes in patients with tic-related OCD, patients with non-tic-related OCD, and healthy controls. Method: The ERN, correct response negativity, and error number were measured during an Eriksen flanker task to assess performance monitoring in 44 youth with a lifetime diagnosis of OCD and 44 matched healthy controls ranging in age from 10 to 19 years. Nine youth with OCD had a lifetime history of tics. Results: ERN amplitude was significantly increased in patients with OCD compared with healthy controls. ERN amplitude was significantly larger in patients with non-tic-related OCD than in patients with tic-related OCD or controls. ERN amplitude had a significant negative correlation with age in healthy controls but not in patients with OCD. Instead, in patients with non-tic-related OCD, ERN amplitude had a significant positive correlation with age at onset of OCD symptoms. ERN amplitude in patients was unrelated to OCD symptom severity, current diagnostic status, or treatment effects. Conclusions: The results provide further evidence of increased error-related brain activity in pediatric OCD. The difference in the ERN between patients with tic-related and those with non-tic-related OCD provides preliminary evidence of a neurobiological difference between these two OCD subtypes. The results indicate the ERN is a trait-like measurement that may serve as a biomarker for non-tic-related OCD. (Contains 2 figures and 2 tables.) (As Provided).
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Update	2017/4/10