Pattern Separation Deficits Following Damage to the Hippocampus

Autor/inn/en	Kirwan, C. Brock; Hartshorn, Andrew; Stark, Shauna M.; Goodrich-Hunsaker, Naomi J.; Hopkins, Ramona O.; Stark, Craig E. L.
Titel	Pattern Separation Deficits Following Damage to the Hippocampus
Quelle	In: Neuropsychologia, 50 (2012) 10, S.2408-2414 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2012.06.011
Schlagwörter	Prediction; Patients; Recognition (Psychology); Computation; Brain; Models; Cognitive Processes; Data Analysis; Tests; Control Groups; Neurological Impairments; Pattern Recognition; Disabilities + Suchen Sie Ihr Suchwort? Vorhersage; Patient; Recognition; Wiedererkennen; Gehirn; Analogiemodell; Cognitive process; Kognitiver Prozess; Auswertung; Examination; Prüfung; Examen; Neurodegenerative Erkrankung; Mustererkennung; Handicap; Behinderung
Abstract	Computational models of hippocampal function propose that the hippocampus is capable of rapidly storing distinct representations through a process known as pattern separation. This prediction is supported by electrophysiological data from rodents and neuroimaging data from humans. Here, we test the prediction that damage to the hippocampus would result in pattern separation deficits by having memory-impaired patients with bilateral hippocampal damage study a series of objects or faces and then perform a modified recognition memory test. In the test phase, participants viewed true repetitions, novel foils, and lures that were perceptually and semantically related to the studied stimuli. Patients with hippocampal damage were unimpaired relative to matched controls in their baseline recognition memory. However, patients were less likely to uniquely identify lures as "similar" than matched controls, indicating an impairment in pattern separation processes following damage to the hippocampus. (Contains 2 tables and 2 figures.) (As Provided).
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Update	2017/4/10