Distinctive Roles for Amygdalar CREB in Reconsolidation and Extinction of Fear Memory

Autor/inn/en	Tronson, Natalie C.; Wiseman, Shari L.; Neve, Rachael L.; Nestler, Eric J.; Olausson, Peter; Taylor, Jane R.
Titel	Distinctive Roles for Amygdalar CREB in Reconsolidation and Extinction of Fear Memory
Quelle	In: Learning & Memory, 19 (2012) 5, S.178-181 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.025783.112
Schlagwörter	Memory; Fear; Information Retrieval; Cognitive Processes; Brain; Auditory Stimuli; Learning Processes + Suchen Sie Ihr Suchwort? Gedächtnis; Furcht; Cognitive process; Kognitiver Prozess; Gehirn; Auditive Stimulation; Learning process; Lernprozess
Abstract	Cyclic AMP response element binding protein (CREB) plays a critical role in fear memory formation. Here we determined the role of CREB selectively within the amygdala in reconsolidation and extinction of auditory fear. Viral overexpression of the inducible cAMP early repressor (ICER) or the dominant-negative mCREB, specifically within the lateral amygdala disrupted reconsolidation of auditory fear memories. In contrast, manipulations of CREB in the amygdala did not modify extinction of fear. These findings suggest that the role of CREB in modulation of memory after retrieval is dynamic and that CREB activity in the basolateral amygdala is involved in fear memory reconsolidation. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10