Heart Activity and Autistic Behavior in Infants and Toddlers with Fragile X Syndrome

Autor/inn/en	Roberts, Jane E.; Tonnsen, Bridgette; Robinson, Ashley; Shinkareva, Svetlana V.
Titel	Heart Activity and Autistic Behavior in Infants and Toddlers with Fragile X Syndrome
Quelle	In: American Journal on Intellectual and Developmental Disabilities, 117 (2012) 2, S.90-102 (13 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1944-7515
DOI	10.1352/1944-7558-117.2.90
Schlagwörter	Intervals; Mental Retardation; Autism; Toddlers; Infants; Brain; Severity (of Disability); Arousal Patterns; Genetic Disorders; Predictor Variables; Child Development; Males; Comparative Analysis; Behavior Problems; Physiology; Neurological Impairments + Suchen Sie Ihr Suchwort? Geistige Behinderung; Autismus; Infant; Infants; Toddler; Kleinkind; Toddlers; Gehirn; Schweregrad; Prädiktor; Kindesentwicklung; Male; Männliches Geschlecht; Physiologie; Neurodegenerative Erkrankung
Abstract	The present study contrasted physiological arousal in infants and toddlers with fragile X syndrome to typically developing control participants and examined physiological predictors early in development to autism severity later in development in fragile X syndrome. Thirty-one males with fragile X syndrome (ages 8-40 months) and 25 age-matched control participants were included. The group with fragile X syndrome showed shorter interbeat intervals (IBIs), lower vagal tone (VT), and less modulation of IBI. Data suggested a nonlinear effect with IBI and autistic behavior; however, a linear effect with VT and autistic behavior emerged. These findings suggest that atypical physiological arousal emerges within the first year and predicts severity of autistic behavior in fragile X syndrome. These relationships are complex and dynamic, likely reflecting endogenous factors assumed to reflect atypical brain function secondary to reduced fragile X mental retardation protein. This research has important implications for the early identification and treatment of autistic behaviors in young children with fragile X syndrome. (As Provided).
Anmerkungen	American Association on Intellectual and Developmental Disabilities. P.O. Box 1897, Lawrence, KS 66044-1897. Tel: 785-843-1235; Fax: 785-843-1274; e-mail: AJMR@allenpress.com; Web site: http://aaidd.allenpress.com
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10