Coaction of Stress and Serotonin Transporter Genotype in Predicting Aggression at the Transition to Adulthood

Autor/inn/en	Conway, Christopher C.; Keenan-Miller, Danielle; Hammen, Constance; Lind, Penelope A.; Najman, Jake M.; Brennan, Patricia A.
Titel	Coaction of Stress and Serotonin Transporter Genotype in Predicting Aggression at the Transition to Adulthood
Quelle	In: Journal of Clinical Child and Adolescent Psychology, 41 (2012) 1, S.53-63 (11 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1537-4416
DOI	10.1080/15374416.2012.632351
Schlagwörter	Structural Equation Models; Chemistry; Investigations; Adults; Adolescents; Foreign Countries; Age Differences; Aggression; Individual Differences; Interviews; Genetics; Science Education; Whites; Minority Groups; Prediction; Australia + Suchen Sie Ihr Suchwort? Chemie; Untersuchung; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Ausland; Age; Difference; Age difference; Altersunterschied; Individueller Unterschied; Interviewing; Interviewtechnik; Humangenetik; Naturwissenschaftliche Bildung; White; Weißer; Ethnische Minderheit; Vorhersage; Australien
Abstract	Despite consistent evidence that serotonin functioning affects stress reactivity and vulnerability to aggression, research on serotonin gene-stress interactions (G x E) in the development of aggression remains limited. The present study investigated variation in the promoter region of the serotonin transporter gene (5-HTTLPR) as a moderator of the stress-aggression association at the transition to adulthood. Multiple informants and multiple measures were used to assess aggression in a cohort of 381 Australian youth (61% female, 93% Caucasian) interviewed at ages 15 and 20. At age 20, semistructured interviews assessed acute and chronic stressors occurring in the past 12 months. Structural equation modeling analyses revealed a significant main effect of chronic stress, but not 5-HTTLPR or acute stress, on increases in aggression at age 20. Consistent with G x E hypotheses, 5-HTTLPR short allele carriers demonstrated greater increments in aggression following chronic stress relative to long allele homozygotes. The strength of chronic stress G x E did not vary according to sex. Variation at 5-HTTLPR appears to contribute to individual differences in aggressive reactions to chronic stress at the transition to adulthood. (Contains 2 tables, 2 figures, and 3 footnotes.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10