Linkage of Speech Sound Disorder to Reading Disability Loci

Autor/inn/en	Smith, Shelley D.; Pennington, Bruce F.; Boada, Richard; Shriberg, Lawrence D.
Titel	Linkage of Speech Sound Disorder to Reading Disability Loci
Quelle	In: Journal of Child Psychology and Psychiatry, 46 (2005) 10, S.1057-1066 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9630
DOI	10.1111/j.1469-7610.2005.01534.x
Schlagwörter	Evidence; Reading Difficulties; Siblings; Speech; Phonological Awareness; Disabilities; Correlation; Genetics; Speech Communication + Suchen Sie Ihr Suchwort? Evidenz; Reading difficulty; Leseschwierigkeit; Sibling; Geschwister; Speaking; Sprechen; Handicap; Behinderung; Korrelation; Humangenetik
Abstract	Background: Speech sound disorder (SSD) is a common childhood disorder characterized by developmentally inappropriate errors in speech production that greatly reduce intelligibility. SSD has been found to be associated with later reading disability (RD), and there is also evidence for both a cognitive and etiological overlap between the two disorders. The present study tested whether SSD is linked to replicated risk loci for RD. Method: One hundred and eleven probands with SSD and their 76 siblings were tested with measures of speech, phonological memory (Nonword Repetition--NWR), and phonological awareness and genotyped for linkage markers on chromosomes 1p36, 6p22, and 15q21. Both single point and multipoint linkage were tested with multiple methods. Results: The speech and NWR phenotypes were linked to the RD loci on chromosomes 6 and 15, with suggestive results for the RD locus on chromosome 1. Conclusions: It now appears that several RD loci are pleiotropic for SSD, extending the findings of Stein et al. (2004) for the RD locus on Chromosome 3. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10