Conduction Aphasia, Sensory-Motor Integration, and Phonological Short-Term Memory--An Aggregate Analysis of Lesion and fMRI Data

Autor/inn/en	Buchsbaum, Bradley R.; Baldo, Juliana; Okada, Kayoko; Berman, Karen F.; Dronkers, Nina; D'Esposito, Mark; Hickok, Gregory
Titel	Conduction Aphasia, Sensory-Motor Integration, and Phonological Short-Term Memory--An Aggregate Analysis of Lesion and fMRI Data
Quelle	In: Brain and Language, 119 (2011) 3, S.119-128 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0093-934X
DOI	10.1016/j.bandl.2010.12.001
Schlagwörter	Sensory Integration; Phonology; Aphasia; Patients; Short Term Memory; Language Impairments; Error Patterns; Brain Hemisphere Functions; Diagnostic Tests; Task Analysis; Psychomotor Skills; Music; Speech; Symptoms (Individual Disorders) + Suchen Sie Ihr Suchwort? Sensorische Integration; Fonologie; Expressive Aphasie; Aphasie; Patient; Kurzzeitgedächtnis; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Fehlertyp; Diagnostic test; Diagnostischer Test; Aufgabenanalyse; Psychomotorische Aktivität; Musik; Speaking; Sprechen; Psychiatrische Symptomatik
Abstract	Conduction aphasia is a language disorder characterized by frequent speech errors, impaired verbatim repetition, a deficit in phonological short-term memory, and naming difficulties in the presence of otherwise fluent and grammatical speech output. While traditional models of conduction aphasia have typically implicated white matter pathways, recent advances in lesions reconstruction methodology applied to groups of patients have implicated left temporoparietal zones. Parallel work using functional magnetic resonance imaging (fMRI) has pinpointed a region in the posterior most portion of the left planum temporale, area Spt, which is critical for phonological working memory. Here we show that the region of maximal lesion overlap in a sample of 14 patients with conduction aphasia perfectly circumscribes area Spt, as defined in an aggregate fMRI analysis of 105 subjects performing a phonological working memory task. We provide a review of the evidence supporting the idea that Spt is an interface site for the integration of sensory and vocal tract-related motor representations of complex sound sequences, such as speech and music and show how the symptoms of conduction aphasia can be explained by damage to this system. (Contains 3 tables and 5 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10