Association of "ADAM10" and "CAMK2A" Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies

Autor/inn/en	Jian, Xue-Qiu; Wang, Ke-Sheng; Wu, Tie-Jian; Hillhouse, Joel J.; Mullersman, Jerald E.
Titel	Association of "ADAM10" and "CAMK2A" Polymorphisms with Conduct Disorder: Evidence from Family-Based Studies
Quelle	In: Journal of Abnormal Child Psychology, 39 (2011) 6, S.773-782 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0091-0627
DOI	10.1007/s10802-011-9524-4
Schlagwörter	Evidence; Alzheimers Disease; Behavior Disorders; Genetics; Depression (Psychology); Evaluation Methods; Whites; Disabilities; Twins; Family (Sociological Unit); Alcoholism; Science Education + Suchen Sie Ihr Suchwort? Evidenz; Humangenetik; White; Weißer; Handicap; Behinderung; Twin; Zwilling; Familie; Alkoholismus; Naturwissenschaftliche Bildung
Abstract	Twin and family studies have shown that genetic factors play a role in the development of conduct disorder (CD). The purpose of this study was to identify genetic variants associated with CD using a family-based association study. We used 4,720 single nucleotide polymorphisms (SNPs) from the Illumina Panel and 11,120 SNPs from the Affymetrix 10K GeneChips genotyped in 155 Caucasian nuclear families from Genetic Analysis Workshop (GAW) 14, a subset from the Collaborative Study on the Genetics of Alcoholism (COGA). 20 SNPs had suggestive associations with CD (p less than 10[superscript -3]), nine of which were located in known genes, including "ADAM10" (rs383902, p = 0.00036) and "CAMK2A" (rs2053053, p = 0.00098). Our results were verified using the International Multi-Center ADHD Genetics Project (IMAGE) dataset. In conclusion, we identified several loci associated with CD. Especially, the two genes ("ADAM10" and "CAMK2A") have been reported to be associated with Alzheimer's disease, bipolar disorder and depression. These findings may serve as a resource for replication in other populations. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10