In Search of HPA Axis Dysregulation in Child and Adolescent Depression

Autor/inn/en	Guerry, John D.; Hastings, Paul D.
Titel	In Search of HPA Axis Dysregulation in Child and Adolescent Depression
Quelle	In: Clinical Child and Family Psychology Review, 14 (2011) 2, S.135-160 (26 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1096-4037
DOI	10.1007/s10567-011-0084-5
Schlagwörter	Evidence; Developmental Disabilities; Psychiatry; Psychopathology; Depression (Psychology); Drug Therapy; Biochemistry; Children; Adolescents; Interdisciplinary Approach; Longitudinal Studies; Role; Physiology + Suchen Sie Ihr Suchwort? Evidenz; Entwicklungsstörung; Psychiatrie; Psychopathologie; Biochemie; Child; Kind; Kinder; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Fächerübergreifender Unterricht; Fächerverbindender Unterricht; Interdisziplinarität; Longitudinal study; Longitudinal method; Longitudinal methods; Längsschnittuntersuchung; Rollen; Physiologie
Abstract	Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis in adults with major depressive disorder is among the most consistent and robust biological findings in psychiatry. Given the importance of the adolescent transition to the development and recurrence of depressive phenomena over the lifespan, it is important to have an integrative perspective on research investigating the various components of HPA axis functioning among depressed young people. The present narrative review synthesizes evidence from the following five categories of studies conducted with children and adolescents: (1) those examining the HPA system's response to the dexamethasone suppression test (DST); (2) those assessing basal HPA axis functioning; (3) those administering corticotropin-releasing hormone (CRH) challenge; (4) those incorporating psychological probes of the HPA axis; and (5) those examining HPA axis functioning in children of depressed mothers. Evidence is generally consistent with models of developmental psychopathology that hypothesize that atypical HPA axis functioning precedes the emergence of clinical levels of depression and that the HPA axis becomes increasingly dysregulated from child to adult manifestations of depression. Multidisciplinary approaches and longitudinal research designs that extend across development are needed to more clearly and usefully elucidate the role of the HPA axis in depression. (Contains 2 tables.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10