Effect of Atomoxetine on Executive Function Impairments in Adults with ADHD

Autor/inn/en	Brown, Thomas E.; Holdnack, James; Saylor, Keith; Adler, Lenard; Spencer, Thomas; Williams, David W.; Padival, Anoop K.; Schuh, Kory; Trzepacz, Paula T.; Kelsey, Douglas
Titel	Effect of Atomoxetine on Executive Function Impairments in Adults with ADHD
Quelle	In: Journal of Attention Disorders, 15 (2011) 2, S.130-138 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1087-0547
DOI	10.1177/1087054709356165
Schlagwörter	Attention Deficit Hyperactivity Disorder; Measures (Individuals); Short Term Memory; Adults; Drug Therapy; Cognitive Processes; Comparative Analysis; Daily Living Skills; Attention Span; Emotional Response; Self Control; Scores; Neurological Impairments; Symptoms (Individual Disorders); Rating Scales; Check Lists + Suchen Sie Ihr Suchwort? Messdaten; Kurzzeitgedächtnis; Cognitive process; Kognitiver Prozess; Alltagsfertigkeit; Emotionales Verhalten; Selbstbeherrschung; Neurodegenerative Erkrankung; Psychiatrische Symptomatik; Rating-Skala; Checkliste
Abstract	Objective: To assess the effect of atomoxetine on ADHD-related executive functions over a 6-month period using the Brown Attention-Deficit Disorder Scale (BADDS) for Adults, a normed, 40-item, self-report scale in a randomized, double-blind, placebo-controlled clinical trial. Method: In a randomized, double-blind clinical trial, adults with ADHD received either atomoxetine 25 to 100 mg/day or placebo for 6 months. Patients completed the BADDS to report their current daily functioning in 5 clusters of ADHD-related impairments of executive functioning: (1) Organizing and Activating to Work; (2) Focusing for Tasks; (3) Regulating Alertness and Effort; (4) Modulating Emotions; and (5) Utilizing Working Memory. Results: Mean scores were significantly more improved in the atomoxetine group compared to the placebo group: total score, -27.0 versus -19.0 (p less than 0.001); all 5 cluster scores, p less than 0.01. Conclusions: Once-daily atomoxetine can improve executive function impairments in adults with ADHD as assessed by the BADDS. (Contains 2 tables and 2 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10