Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome

Autor/inn/en	Yuhas, Jennifer; Cordeiro, Lisa; Tassone, Flora; Ballinger, Elizabeth; Schneider, Andrea; Long, James M.; Ornitz, Edward M.; Hessl, David
Titel	Brief Report: Sensorimotor Gating in Idiopathic Autism and Autism Associated with Fragile X Syndrome
Quelle	In: Journal of Autism and Developmental Disorders, 41 (2011) 2, S.248-253 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-010-1040-9
Schlagwörter	Autism; Genetic Disorders; Inhibition; Neurological Impairments; Comparative Analysis; Pervasive Developmental Disorders + Suchen Sie Ihr Suchwort? Autismus; Hemmung; Neurodegenerative Erkrankung
Abstract	Prepulse inhibition (PPI) may useful for exploring the proposed shared neurobiology between idiopathic autism and autism caused by FXS. We compared PPI in four groups: typically developing controls (n = 18), FXS and autism (FXS+A; n = 15), FXS without autism spectrum disorder (FXS-A; n = 17), and idiopathic autism (IA; n = 15). Relative to controls, the FXS+A (p less than 0.002) and FXS-A (p less than 0.003) groups had impaired PPI. The FXS+A (p less than 0.01) and FXS-A (p less than 0.03) groups had lower PPI than the IA group. Prolonged startle latency was seen in the IA group. The differing PPI profiles seen in the FXS+A and IA indicates these groups may not share a common neurobiological abnormality of sensorimotor gating. (Contains 3 tables and 4 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10