Antagonism of Lateral Amygdala Alpha1-Adrenergic Receptors Facilitates Fear Conditioning and Long-Term Potentiation

Autor/inn/en	Lazzaro, Stephanie C.; Hou, Mian; Cunha, Catarina; LeDoux, Joseph E.; Cain, Christopher K.
Titel	Antagonism of Lateral Amygdala Alpha1-Adrenergic Receptors Facilitates Fear Conditioning and Long-Term Potentiation
Quelle	In: Learning & Memory, 17 (2010) 10, S.489-493 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1918210
Schlagwörter	Posttraumatic Stress Disorder; Conditioning; Long Term Memory; Fear; Brain Hemisphere Functions; Biochemistry; Attention; Role; Learning Processes; Cues; Drug Use; Hypertension + Suchen Sie Ihr Suchwort? Langzeitgedächtnis; Furcht; Biochemie; Aufmerksamkeit; Rollen; Learning process; Lernprozess; Stichwort; Drug consumption; Substance abuse; Drogenkonsum; Bluthochdruck; Hypertonie
Abstract	Norepinephrine receptors have been studied in emotion, memory, and attention. However, the role of alpha1-adrenergic receptors in fear conditioning, a major model of emotional learning, is poorly understood. We examined the effect of terazosin, an alpha1-adrenergic receptor antagonist, on cued fear conditioning. Systemic or intra-lateral amygdala terazosin delivered before conditioning enhanced short- and long-term memory. Terazosin delivered after conditioning did not affect consolidation. In vitro, terazosin impaired lateral amygdala inhibitory postsynaptic currents leading to facilitation of excitatory postsynaptic currents and long-term potentiation. Since alpha1 blockers are prescribed for hypertension and post-traumatic stress disorder, these results may have important clinical implications. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10