Baseline Cognition, Behavior, and Motor Skills in Children with New-Onset, Idiopathic Epilepsy

Autor/inn/en	Bhise, Vikram V.; Burack, Gail D.; Mandelbaum, David E.
Titel	Baseline Cognition, Behavior, and Motor Skills in Children with New-Onset, Idiopathic Epilepsy
Quelle	In: Developmental Medicine & Child Neurology, 52 (2010) 1, S.22-26 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0012-1622
DOI	10.1111/j.1469-8749.2009.03404.x
Schlagwörter	Epilepsy; Seizures; Memory; Cognitive Development; Psychomotor Skills; Child Behavior; Genetics; Measures (Individuals); Intelligence Quotient; Scores; Classification; Attention; Vocabulary; Auditory Stimuli; Learning Processes; Visual Stimuli; Cognitive Processes + Suchen Sie Ihr Suchwort? Epilepsie; Anfallsleiden; Gedächtnis; Kognitive Entwicklung; Psychomotorische Aktivität; Humangenetik; Messdaten; Intelligenzquotient; Classification system; Klassifikation; Klassifikationssystem; Aufmerksamkeit; Wortschatz; Auditive Stimulation; Learning process; Lernprozess; Cognitive process; Kognitiver Prozess
Abstract	Aim: Epilepsy is associated with difficulties in cognition and behavior in children. These problems have been attributed to genetics, ongoing seizures, psychosocial issues, underlying abnormality of the brain, and/or antiepileptic drugs. In a previous study, we found baseline cognitive differences between children with partial versus generalized and convulsive versus non-convulsive seizures. Measures in that study focused primarily on IQ scores. In the present study, we assessed baseline function with respect to new learning, attention, and memory, thus providing a more comprehensive profile than our previous study. Method: We examined 57 children (42 females, 15 males), aged 6 to 17 years (mean 10y 1mo, SD 2y 9mo), with new-onset, idiopathic epilepsy, using tests of cognitive function reflective of new learning, memory, and attention. Seizures were classified as generalized convulsive (n=5), generalized non-convulsive (n=18), or focal (n=34). Focal seizures were divided into unilateral versus bilateral independent foci, and presence versus absence of secondary generalization. Results: Attention was a particular area of weakness across all groups. The Vocabulary score of an intelligence screen was higher for the focal seizure groups (p=0.012), primarily because of a difference between the unilateral focal and the primary generalized groups (p less than 0.047). Children with generalized, non-convulsive seizures performed significantly worse than the focal group on a measure of short-term auditory memory (p=0.019). All groups performed poorly on a test of visual-motor speed. Interpretation: These findings suggest intrinsic abnormalities in children with new-onset, idiopathic epilepsy at baseline. (As Provided).
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Update	2017/4/10