Age Differences in Perseveration: Cognitive and Neuroanatomical Mediators of Performance on the Wisconsin Card Sorting Test

Autor/inn/en	Head, Denise; Kennedy, Kristen M.; Rodrigue, Karen M.; Raz, Naftali
Titel	Age Differences in Perseveration: Cognitive and Neuroanatomical Mediators of Performance on the Wisconsin Card Sorting Test
Quelle	In: Neuropsychologia, 47 (2009) 4, S.1200-1203 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0028-3932
DOI	10.1016/j.neuropsychologia.2009.01.003
Schlagwörter	Integrity; Neurology; Children; Age Differences; Short Term Memory; Path Analysis; Cognitive Processes; Tests; Brain Hemisphere Functions; Diagnostic Tests; Measures (Individuals); Young Adults; Older Adults + Suchen Sie Ihr Suchwort? Integrität; Neurologie; Child; Kind; Kinder; Age; Difference; Age difference; Altersunterschied; Kurzzeitgedächtnis; Pfadanalyse; Cognitive process; Kognitiver Prozess; Examination; Prüfung; Examen; Diagnostic test; Diagnostischer Test; Messdaten; Young adult; Junger Erwachsener; Älterer Erwachsener
Abstract	Aging effects on the Wisconsin Card Sorting Test (WCST) are fairly well established but the mechanisms of the decline are not clearly understood. In this study, we examined the cognitive and neural mechanisms mediating age-related increases in perseveration on the WCST. MRI-based volumetry and measures of selected executive functions in conjunction with the WCST were obtained in a sample of 117 healthy young and older adults. Path analysis indicated that age-related increase in perseveration is completely accounted for by declines in processing speed and temporal processing, deficits in working memory mediated by decreased prefrontal cortical volume, and the indirect influence of prefrontally-mediated declines in inhibition via working memory. We conclude that age-related increase in perseveration is indeed differentially dependent on the integrity of prefrontal cortex and on declines in selected cognitive processes dependent on this region. (Contains 1 figure.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10