A Comparative Study of Clinical Correlates in Schizophrenia with Onset in Childhood, Adolescence and Adulthood

Autor/inn/en	Biswas, Parthasarathy; Malhotra, Savita; Malhotra, Anil; Gupta, Nitin
Titel	A Comparative Study of Clinical Correlates in Schizophrenia with Onset in Childhood, Adolescence and Adulthood
Quelle	In: Journal of Indian Association for Child and Adolescent Mental Health, 2 (2006) 1, S.18-30 (13 Seiten) PDF als Volltext kostenfreie Datei Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0973-1342
Schlagwörter	Schizophrenia; Intelligence Quotient; Psychopathology; Children; Patients; Measures (Individuals); Genetics; Profiles; Foreign Countries; Correlation; Child Health; Age Differences; Adolescents; Adults; Comparative Analysis; Socioeconomic Influences; Demography; Individual Characteristics; Genetic Disorders; Academic Achievement; Symptoms (Individual Disorders); Self Destructive Behavior; Suicide; Drug Therapy; Behavior Disorders; Outcomes of Treatment; India; Wechsler Adult Intelligence Scale + Suchen Sie Ihr Suchwort? Schizophrenie; Intelligenzquotient; Psychopathologie; Child; Kind; Kinder; Patient; Messdaten; Humangenetik; Charakterisierung; Profilanalyse; Ausland; Korrelation; Age; Difference; Age difference; Altersunterschied; Adolescent; Adolescence; Adoleszenz; Jugend; Jugendalter; Jugendlicher; Sozioökonomischer Faktor; Demografie; Personality characteristic; Personality traits; Persönlichkeitsmerkmal; Schulleistung; Psychiatrische Symptomatik; Self destrucive behaviour; Selbstzerstörung; Selbstmord; Indien
Abstract	Background: Childhood onset schizophrenia (COS) is a rare disorder. Comparative data on the effect of differential age of onset on clinical profile in schizophrenia are very few. Method: Subjects with COS (n = 15), adolescence onset schizophrenia (AdOS, n = 20) and adulthood onset schizophrenia (AOS, n = 20) were compared on socio-demographic, clinical and genetic history parameters using Instrument for the Retrospective Assessment of the Onset of Schizophrenia (IRAOS), Positive and Negative Symptoms Scale (PANSS), Family Instrument for Genetic Studies (FIGS), Wechsler's Adult Intelligence Scale-Revised WAIS-R), Malin's Intelligence Scale for Indian Children (MISIC) and WHO Life Chart Schedule (WHO LCS). Results: Significantly higher rate of socioeconomic dependence, poorer academic performance, and non-paranoid subtype was seen in the COS group as compared to the AdOS and AOS. The total score on PANSS was maximum in the COS group with AdOS taking an intermediate position. COS patients had more somatic and obsessive symptoms whereas, AdOS patients had more self-injurious behaviour and suicidal attempts. The response to typical antipsychotic medication was poorer in the COS group as compared to the other two groups. In spite of treatment with atypical antipsychotics (including clozapine), 1/3rd of the COS patients continued to show limited response. The COS group scored least on the Mean IQ. The outcome was significantly poorer in patients of COS (33%), and it correlated significantly with low IQ. Conclusions: COS seems to be a more severe form of the schizophrenic illness with high degree of socioeconomic dependence, poorer response to treatment, greater and more florid psychopathology, poorer course and outcome, greater neurocognitive deficits and qualitative differences in the type of schizophrenia and non-specific symptom profile as compared to the later onset schizophrenias. (Contains 3 tables.) (As Provided).
Anmerkungen	Indian Association for Child and Adolescent Mental Health. e-mail: jiacam@gmail.com; Web site: http://www.jiacam.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10