Cocaine Self-Administration Alters the Relative Effectiveness of Multiple Memory Systems during Extinction

Autor/inn/en	Gabriele, Amanda; Setlow, Barry; Packard, Mark G.
Titel	Cocaine Self-Administration Alters the Relative Effectiveness of Multiple Memory Systems during Extinction
Quelle	In: Learning & Memory, 16 (2009) 5, S.296-299 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1253409
Schlagwörter	Cocaine; Memory; Animals; Reinforcement; Habit Formation; Intervals + Suchen Sie Ihr Suchwort? Kokain; Gedächtnis; Animal; Tier; Tiere; Positive Verstärkung
Abstract	Rats were trained to run a straight-alley maze for an oral cocaine or sucrose vehicle solution reward, followed by either response or latent extinction training procedures that engage neuroanatomically dissociable "habit" and "cognitive" memory systems, respectively. In the response extinction condition, rats performed a runway approach response to an empty fluid well. In the latent extinction condition, rats were placed at the empty fluid well without performing a runway approach response. Rats trained with the sucrose solution displayed normal extinction behavior in both conditions. In contrast, rats trained with the cocaine solution showed normal response extinction but impaired latent extinction. The selective impairment of latent extinction indicates that oral cocaine self-administration alters the relative effectiveness of multiple memory systems during subsequent extinction training. (Contains 2 figures.) (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10