Differential Involvement of Dopamine D1 Receptor and MEK Signaling Pathway in the Ventromedial Prefrontal Cortex in Consolidation and Reconsolidation of Recognition Memory

Autor/inn/en	Maroun, Mouna; Akirav, Irit
Titel	Differential Involvement of Dopamine D1 Receptor and MEK Signaling Pathway in the Ventromedial Prefrontal Cortex in Consolidation and Reconsolidation of Recognition Memory
Quelle	In: Learning & Memory, 16 (2009) 4, S.243-247 (5 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1245009
Schlagwörter	Recognition (Psychology); Memory; Animals; Experiments; Control Groups; Short Term Memory; Brain + Suchen Sie Ihr Suchwort? Recognition; Wiedererkennen; Gedächtnis; Animal; Tier; Tiere; Erprobung; Kurzzeitgedächtnis; Gehirn
Abstract	We investigated MEK and D1 receptors in the ventromedial prefrontal cortex (vmPFC) in consolidation and reconsolidation of recognition memory in rats nonhabituated to the experimental context (NH) or with reduced arousal due to extensive prior habituation (H). The D1 receptor antagonist enhanced consolidation and impaired reconsolidation in NH but impaired consolidation with no effect on reconsolidation in H. The D1 receptor agonist had no effect on consolidation in either H or NH but impaired reconsolidation in both groups. The MEK inhibitor impaired consolidation and reconsolidation, regardless of arousal. Thus, vmPFC D1 receptors and MEK show differential involvement in memory and arousal. (Contains 3 figures.) (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10