Storage or Retrieval Deficit: The Yin and Yang of Amnesia

Autor/inn/en	Hardt, Oliver; Wang, Szu-Han; Nader, Karim
Titel	Storage or Retrieval Deficit: The Yin and Yang of Amnesia
Quelle	In: Learning & Memory, 16 (2009) 4, S.224-230 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1267409
Schlagwörter	Memory; Brain; Foreign Countries; Animals; Learning Processes; Neurological Impairments; Fear; Laboratory Procedures; Animal Behavior; Experiments; Universities; Canada + Suchen Sie Ihr Suchwort? Gedächtnis; Gehirn; Ausland; Animal; Tier; Tiere; Learning process; Lernprozess; Neurodegenerative Erkrankung; Furcht; Laboruntersuchung; Tierverhalten; Erprobung; University; Universität; Kanada
Abstract	To this day, it remains unresolved whether experimental amnesia reflects failed memory storage or the inability to retrieve otherwise intact memory. Methodological as well as conceptual reasons prevented deciding between these two alternatives: The absence of recovery from amnesia is typically taken as supporting storage impairment interpretations; however, this absence of recovery does not positively demonstrate nonexistence of memory, allowing for alternative interpretations of amnesia as impairment of memory retrieval. To address this shortcoming, we present a novel approach to study the nature of amnesia that makes positive, i.e., falsifiable, predictions for the absence of memory. Applying this paradigm, we demonstrate here that infusing anisomycin into the dorsal hippocampus induces amnesia by impairing memory storage, not retrieval. (Contains 2 tables and 4 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10