Enhanced Generalization of Auditory Conditioned Fear in Juvenile Mice

Autor/inn/en	Ito, Wataru; Pan, Bing-Xing; Yang, Chao; Thakur, Siddarth; Morozov, Alexei
Titel	Enhanced Generalization of Auditory Conditioned Fear in Juvenile Mice
Quelle	In: Learning & Memory, 16 (2009) 3, S.187-192 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1190809
Schlagwörter	Animals; Generalization; Fear; Conditioning; Models; Auditory Stimuli; Associative Learning; Learning Processes + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Furcht; Analogiemodell; Auditive Stimulation; Learning process; Lernprozess
Abstract	Increased emotionality is a characteristic of human adolescence, but its animal models are limited. Here we report that generalization of auditory conditioned fear between a conditional stimulus (CS+) and a novel auditory stimulus is stronger in 4-5-wk-old mice (juveniles) than in their 9-10-wk-old counterparts (adults), whereas nonassociative sensitization induced by foot shock (US) and the ability to discriminate CS+ from an explicitly unpaired stimulus (CS-) are not dependent on age. These results suggest that aversive associations are less precise in juvenile mice and can more easily produce conditional responses to stimuli different from CS+. Yet, through the explicit unpairing of CS- from US during training, juveniles are able to overcome this greater fear generalization and learn that CS- is not associated with foot shock. (Contains 5 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10