Response Speed, Contingent Negative Variation and P300 in Alzheimer's Disease and MCI

Autor/inn/en	van Deursen, J. A.; Vuurman, E. F. P. M.; Smits, L. L.; Verhey, F. R. J.; Riedel, W. J.
Titel	Response Speed, Contingent Negative Variation and P300 in Alzheimer's Disease and MCI
Quelle	In: Brain and Cognition, 69 (2009) 3, S.592-599 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2008.12.007
Schlagwörter	Alzheimers Disease; Mental Disorders; Patients; Reaction Time; Cognitive Processes; Brain; Control Groups; Differences; Correlation + Suchen Sie Ihr Suchwort? Mental illness; Geisteskrankheit; Patient; Reaktionsvermögen; Cognitive process; Kognitiver Prozess; Gehirn; Unterscheiden; Korrelation
Abstract	Background: Decreased speed of information processing is a hallmark of Alzheimer's disease (AD) and mild cognitive impairment (MCI). Recent studies suggest that response speed (RS) measures are very sensitive indicators of changes in longitudinal follow-up studies. Insight into the psycho-physiological underpinnings of slowed RS can be provided by measuring the associated event-related potentials (ERP). Aims: The current study aims to investigate the relation between RS and its psycho-physiological correlates in AD and MCI. Methods: Fifteen psychoactive drug-naive AD patients, 20 MCI patients and twenty age-matched, healthy control subjects participated. Response speed was measured during a simple (SRT) and choice reaction time task (CRT). An oddball and contingent negative variation (CNV) paradigm were used to elicit ERP. To evaluate test-retest reliability (TRR), subjects underwent a similar assessment one week after the first. Results: The SRT and CRT distinguished the patient groups significantly. The P300 amplitude and latency also distinguished the groups and showed a significant correlation with response speed. The CNV amplitude did not reveal a significant difference between groups and also showed a low TRR. The TRR of the SRT, CRT and P300 amplitude and latency in general was moderate to high. The current study suggests that response speed measures on a behavioural and psycho-physiological level deserve attention as a possible marker in the diagnosis and follow-up of AD. (Contains 4 tables and 2 figures.) (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10