Boundary Conditions for the Maintenance of Memory by PKM[zeta] in Neocortex

Autor/inn/en	Shema, Reul; Hazvi, Shoshi; Sacktor, Todd C.; Dudai, Yadin
Titel	Boundary Conditions for the Maintenance of Memory by PKM[zeta] in Neocortex
Quelle	In: Learning & Memory, 16 (2009) 2, S.122-128 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.1183309
Schlagwörter	Brain; Animals; Conditioning; Perception; Cognitive Processes; Memory + Suchen Sie Ihr Suchwort? Gehirn; Animal; Tier; Tiere; Wahrnehmung; Cognitive process; Kognitiver Prozess; Gedächtnis
Abstract	We report here that ZIP, a selective inhibitor of the atypical protein kinase C isoform PKM[zeta], abolishes very long-term conditioned taste aversion (CTA) associations in the insular cortex of the behaving rat, at least 3 mo after encoding. The effect of ZIP is not replicated by a general serine/threonine protein kinase inhibitor that is relatively ineffective toward PKM[zeta], is independent of the intensity of training and the perceptual quality of the taste saccharin (conditioned stimulus, CS), and does not affect the ability of the insular cortex to re-encode the same specific CTA association again. The memory trace is, however, insensitive to ZIP during or immediately after training. This implies that the experience-dependent cellular plasticity mechanism targeted by ZIP is established following a brief time window after encoding, consistent with the standard period of cellular consolidation, but then, once established, does not consolidate further to gain immunity to the amnesic agent. Hence, we conclude that PKM[zeta] is not involved in short-term CTA memory, but is a critical component of the cortical machinery that stores long- and very long-term CTA memories. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10