Noradrenergic Control of Odor Recognition in a Nonassociative Olfactory Learning Task in the Mouse

Autor/inn/en	Veyrac, Alexandra; Nguyen, Veronique; Marien, Marc; Didier, Anne; Jourdan, Francois
Titel	Noradrenergic Control of Odor Recognition in a Nonassociative Olfactory Learning Task in the Mouse
Quelle	In: Learning & Memory, 14 (2007) 12, S.847-854 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.708807
Schlagwörter	Animals; Learning Processes; Stimuli; Sensory Experience; Drug Use; Sensory Training; Recall (Psychology) + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Learning process; Lernprozess; Anreizsystem; Sinnerfahrung; Drug consumption; Substance abuse; Drogenkonsum; Sensorische Erziehung; Abberufung
Abstract	The present study examined the influence of pharmacological modulations of the locus coeruleus noradrenergic system on odor recognition in the mouse. Mice exposed to a nonrewarded olfactory stimulation (training) were able to memorize this odor and to discriminate it from a new odor in a recall test performed 15 min later. At longer delays (30 or 60 min), the familiar odor was no longer retained, and both stimuli were perceived as new ones. Following a post-training injection of the [alpha][subscript 2]-adrenoceptor antagonist dexefaroxan, the familiar odor was still remembered 30 min after training. In contrast, both the [alpha][subscript 2]-adrenoceptor agonist UK 14304 and the noradrenergic neurotoxin DSP-4 prevented the recognition of the familiar odor 15 min after the first exposure. Noradrenaline release in the olfactory bulb, assessed by measurement of the extracellular noradrenaline metabolite normetanephrine, was increased by 62% following dexefaroxan injection, and was decreased by 38%-44% after treatment with UK 14304 and DSP-4. Performance of mice in the recall test was reduced by a post-training injection of the [beta]-adrenoceptor antagonist propranolol or the [alpha][subscript 1]-antagonist prazosin, thus implicating a role for [beta]- and [alpha][subscript 1]-adrenoceptors in the facilitating effects of noradrenaline on short-term olfactory recognition in this model. (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10