Facilitation of Fear Extinction by D-Cycloserine: Theoretical and Clinical Implications

Autor/inn/en	Cranney, Jacquelyn; Richardson, Rick; Ledgerwood, Lana
Titel	Facilitation of Fear Extinction by D-Cycloserine: Theoretical and Clinical Implications
Quelle	In: Learning & Memory, 11 (2004) 5, S.510-516 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.78204
Schlagwörter	Biochemistry; Drug Therapy; Clinical Psychology; Data Interpretation; Learning Processes; Behavior Modification; Fear; Anxiety + Suchen Sie Ihr Suchwort? Biochemie; Klinische Psychologie; Data evaluation; Datenauswertung; Learning process; Lernprozess; Behaviour modification; Verhaltensänderung; Furcht; Angst
Abstract	Anxiety disorders are among the most common psychological disturbances in the industrialized world. Current behavioral therapy procedures for these disorders are somewhat effective, but their efficacy could be substantially improved. Because these procedures are largely based on the process of extinction, manipulations that enhance extinction may lead to improvements in treatment effectiveness. We review the evidence that D-cycloserine (DCS), a partial NMDA agonist, facilitates extinction of learned fear in rats. Although only a few studies have examined the effects of DCS on extinction of learned fear, this work suggests that this drug may have a number of potential clinical benefits. In addition, attempts at interpreting this research illustrate our limited understanding of the processes involved in extinction. (Contains 4 figures.) (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10