Literaturnachweis - Detailanzeige
| Autor/inn/en | Harley, Carolyn W.; Darby-King, Andrea; McCann, Jennifer; McLean, John H. |
|---|---|
| Titel | [beta]1-Adrenoceptor or [alpha]1-Adrenoceptor Activation Initiates Early Odor Preference Learning in Rat Pups: Support for the Mitral Cell/cAMP Model of Odor Preference Learning |
| Quelle | In: Learning & Memory, 13 (2006) 1, S.8-13 (6 Seiten)
PDF als Volltext |
| Sprache | englisch |
| Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
| ISSN | 1072-0502 |
| Schlagwörter | Molecular Structure; Learning Processes; Animals; Brain; Cognitive Processes; Sensory Experience |
| Abstract | We proposed that mitral cell [beta]1-adrenoceptor activation mediates rat pup odor preference learning. Here we evaluate [beta]1-, [beta]2-, [alpha]1-, and [alpha]2-adrenoceptor agonists in such learning. The [beta]1-adrenoceptor agonist, dobutamine, and the [alpha]1-adrenoceptor agonist, phenylephrine, induced learning, and both exhibited an inverted U-curve dose-response relationship to odor preference learning. Phenylephrine-induced learning occurred in the presence of propranolol to prevent indirect activation of [beta]-adrenoceptors. [alpha]1-Adrenoceptor mediation may represent a novel mechanism inducing learning or may increase cAMP in mitral cells via indirect activation of GABA[subscript B] receptors. Neither the [beta]2-adrenoceptor agonist, salbutamol, nor the [alpha]2-adrenoceptor agonist, clonidine, induced learning. (Contains 6 figures.) (Author). |
| Anmerkungen | Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/ |
| Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
| Update | 2017/4/10 |
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