[[superscript 3]H]-Flunitrazepam-Labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study

Autor/inn/en	Guptill, Jeffrey T.; Booker, Anne B.; Gibbs, Terrell T.; Kemper, Thomas L.; Bauman, Margaret L.; Blatt, Gene J.
Titel	[[superscript 3]H]-Flunitrazepam-Labeled Benzodiazepine Binding Sites in the Hippocampal Formation in Autism: A Multiple Concentration Autoradiographic Study
Quelle	In: Journal of Autism and Developmental Disorders, 37 (2007) 5, S.911-920 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-006-0226-7
Schlagwörter	Autism; Brain; Drug Therapy; Comparative Analysis; Neurology; Pharmacology; Biochemistry + Suchen Sie Ihr Suchwort? Autismus; Gehirn; Neurologie; Arzneikunde; Biochemie
Abstract	Increasing evidence indicates that the GABAergic system in cerebellar and limbic structures is affected in autism. We extended our previous study that found reduced [[superscript 3]H] flunitrazepam-labeled benzodiazepine sites in the autistic hippocampus to determine whether this reduction was due to a decrease in binding site number (B [subscript max]) or altered affinity (K [subscript d]) to bind to the ligand. Quantitation of hippocampal lamina demonstrated a 20% reduction in B [subscript max] indicating a trend toward a decreased number of benzodiazepine binding sites in the autistic group but normal K[subscript d] values. A reduction in the number of hippocampal benzodiazepine binding sites suggests alterations in the modulation of GABA [subscript A] receptors in the presence of GABA in the autistic brain, possibly resulting in altered inhibitory functioning of hippocampal circuitry. (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10