Cognitive Function and Depression in Symptom Resolution in Schizophrenia Patients Treated with an Atypical Antipsychotic

Autor/inn/en	Stip, Emmanuel; Mancini-Marie, Adham
Titel	Cognitive Function and Depression in Symptom Resolution in Schizophrenia Patients Treated with an Atypical Antipsychotic
Quelle	In: Brain and Cognition, 55 (2004) 3, S.463-465 (3 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0278-2626
DOI	10.1016/j.bandc.2004.02.066
Schlagwörter	Schizophrenia; Patients; Drug Therapy; Neuropsychology; Depression (Psychology); Symptoms (Individual Disorders); Multiple Regression Analysis; Cognitive Measurement + Suchen Sie Ihr Suchwort? Schizophrenie; Patient; Neuropsychologie; Psychiatrische Symptomatik
Abstract	Objective: To investigate which cognitive and affective features contribute most to responder/non-responder group separation during a switching trial with atypical antipsychotic. Design: A prospective open trial with an atypical antipsychotic (olanzapine). Patients: One hundred and thirty-four patients meeting diagnostic criteria for schizophrenia, schizophreniform or schizoaffective disorder began an 8-week open-label olanzapine treatment at a dose of 5mg/day which was increased to 10mg/day after one week. Interventions: Olanzapine during 8 weeks. Patients were considered as responders if their BPRS score decreased of at least 20% (n=96) and non-responders if it did not (n=38). Neuropsychological assessments were carried out at baseline, at four and at eight weeks. Results: Neurocognitive measures were analyzed for discriminate factors between responder and non-responder groups. A regression analysis was applied to explain the effects of depression on each cognitive variable. Depression was found to be a weak discriminant factor, however this finding could not firmly establish that depression is a potential factor in explaining deficits and improvements in cognition. (Author).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2017/4/10