Prenatal Trace Elements Mixture Is Associated with Learning Deficits on a Behavioral Acquisition Task among Young Children

Autor/inn/en	Merced-Nieves, Francheska M.; Chelonis, John; Pantic, Ivan; Schnass, Lourdes; Téllez-Rojo, Martha M.; Braun, Joseph M.; Paule, Merle G.; Wright, Rosalind J.; Wright, Robert O.; Curtin, Paul
Titel	Prenatal Trace Elements Mixture Is Associated with Learning Deficits on a Behavioral Acquisition Task among Young Children
Quelle	In: New Directions for Child and Adolescent Development, (2022) 181-182, S.53-66 (14 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Merced-Nieves, Francheska M.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1520-3247
DOI	10.1002/cad.20458
Schlagwörter	Young Children; Foreign Countries; Learning Problems; Prenatal Influences; Hazardous Materials; Task Analysis; Cognitive Development; Child Development; Child Behavior; Mexico (Mexico City) + Suchen Sie Ihr Suchwort? Frühe Kindheit; Ausland; Lernproblem; Pränataler Einfluss; Hazardous substance; Gefahrstoff; Aufgabenanalyse; Kognitive Entwicklung; Kindesentwicklung
Abstract	Children are exposed to many trace elements throughout their development. Given their ubiquity and potential to have effects on children's neurodevelopment, these exposures are a public health concern. This study sought to identify trace element mixture-associated deficits in learning behavior using operant testing in a prospective cohort. We included 322 participants aged 6-7 years recruited in Mexico City with complete data on prenatal trace elements measurements (third trimester blood lead and manganese levels, and & urine cadmium and arsenic levels), demographic covariates, and the Incremental Repeated Acquisition (IRA), an associative learning task. Weighted quantile sum (WQS) regression models were used to estimate the joint association of the mixture of all four trace elements and IRA performance. Performance was adversely impacted by the mixture, with different elements relating to different aspects of task performance suggesting that prenatal exposure to trace element mixtures yields a broad dysregulation of learning behavior. (As Provided).
Anmerkungen	Wiley. Available from: John Wiley & Sons, Inc. 111 River Street, Hoboken, NJ 07030. Tel: 800-835-6770; e-mail: cs-journals@wiley.com; Web site: https://www.wiley.com/en-us
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01