Literaturnachweis - Detailanzeige
Autor/inn/en | Horinouchi, Tomoko; Maeyama, Kaori; Nagai, Masashi; Mizobuchi, Masami; Takagi, Yasuko; Okada, Yuka; Kato, Takeshi; Nishimura, Mio; Kawasaki, Yoko; Yoshioka, Mieko; Takada, Satoshi; Matsumoto, Hisayuki; Nakamachi, Yuji; Saegusa, Jun; Fukushima, Sachiyo; Fujioka, Kazumichi; Tomioka, Kazumi; Nagase, Hiroaki; Nozu, Kandai; Iijima, Kazumoto; Nishimura, Noriyuki |
---|---|
Titel | Genetic Analysis of "UGT1A1" Polymorphisms Using Preserved Dried Umbilical Cord for Assessing the Potential of Neonatal Jaundice as a Risk Factor for Autism Spectrum Disorder in Children |
Quelle | In: Journal of Autism and Developmental Disorders, 52 (2022) 2, S.483-489 (7 Seiten)
PDF als Volltext |
Zusatzinformation | ORCID (Nishimura, Noriyuki) |
Sprache | englisch |
Dokumenttyp | gedruckt; online; Zeitschriftenaufsatz |
ISSN | 0162-3257 |
DOI | 10.1007/s10803-021-04941-w |
Schlagwörter | Neonates; Physiology; Biochemistry; Children; At Risk Persons; Autism; Pervasive Developmental Disorders; Symptoms (Individual Disorders) |
Abstract | Neonatal jaundice has been suggested as a perinatal risk factor for autism spectrum disorder (ASD). We examined UGT1A1 polymorphisms to assess the potential of neonatal jaundice as a risk factor for ASD in children by using DNA extracted from preserved umbilical cord. In total, 79 children with ASD were genotyped for "UGT1A1*28" (c.-41-40dup), "UGT1A1*6" (c.211 G > A), and "UGT1A1*27" (c.686 C > A). The allele frequency of "UGT1A1*6" (OR = 1.34, p = 0.26) and "UGT1A1*28" (OR = 0.80, p = 0.54) and the prevalence of "UGT1A1*28/*6" diplotypes did not differ significantly from those in the control population. No "UGT1A1*27" allele was detected in the subjects. ASD symptom assessment scores were not associated with "UGT1A1*28/*6/*27" genotypes or "UGT1A1*28/*6" diplotypes. These results suggest that neonatal jaundice is not significantly associated with ASD. (As Provided). |
Anmerkungen | Springer. Available from: Springer Nature. One New York Plaza, Suite 4600, New York, NY 10004. Tel: 800-777-4643; Tel: 212-460-1500; Fax: 212-460-1700; e-mail: customerservice@springernature.com; Web site: https://link.springer.com/ |
Erfasst von | ERIC (Education Resources Information Center), Washington, DC |
Update | 2024/1/01 |