Language Decline Characterizes Amnestic Mild Cognitive Impairment Independent of Cognitive Decline

Autor/inn/en	Sherman, Janet Cohen; Henderson, Charles R.; Flynn, Suzanne; Gair, James W.; Lust, Barbara
Titel	Language Decline Characterizes Amnestic Mild Cognitive Impairment Independent of Cognitive Decline
Quelle	In: Journal of Speech, Language, and Hearing Research, 64 (2021) 11, S.4287-4307 (21 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Sherman, Janet Cohen)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1092-4388
Schlagwörter	Cognitive Ability; Psycholinguistics; Phrase Structure; Alzheimers Disease; Language Impairments; Aging (Individuals); Comparative Analysis; Memory; Screening Tests; Language Tests; Prediction; Speech Communication; Syntax; Semantics; Language Processing; Scores; Neurological Impairments + Suchen Sie Ihr Suchwort? Denkfähigkeit; Psycholinguistik; Phrasenstruktur; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech handicap; Speech handicaps; Speech impairment; Speech impairments; Language handicaps; Sprachbehinderung; Aging; Altern; Gedächtnis; Screening-Verfahren; Language test; Sprachtest; Vorhersage; Semantik; Sprachverarbeitung; Neurodegenerative Erkrankung
Abstract	Purpose: This research investigated the nature of cognitive decline in prodromal Alzheimer's disease (AD), particularly in mild cognitive impairment, amnestic type (aMCI). We assessed language in aMCI as compared with healthy aging (HA) and healthy young (HY) with new psycholinguistic assessment of complex sentences, and we tested the degree to which deficits on this language measure relate to performance in other general cognitive domains such as memory. Method: Sixty-one individuals with aMCI were compared with 24 HA and 10 HY adults on a psycholinguistic measure of complex sentence production (relative clauses). In addition, HA, HY, and a subset of the aMCI participants (n = 22) were also tested on a multidomain cognitive screen, the Addenbrooke's Cognitive Examination-Revised (ACE-R), and on a verbal working memory Brown-Peterson (BP) test. General and generalized linear mixed models were used to test psycholinguistic results and to test whether ACE-R and BP performance predicted performance on the psycholinguistic test similarly in the aMCI and HA groups. Results: On the psycholinguistic measure, sentence imitation was significantly deficited in aMCI in comparison with that in HA and HY. Experimental factorial designs revealed that individuals with aMCI had particular difficulty repeating sentences that especially challenged syntax-semantics integration. As expected, the aMCI group also performed significantly below the HY and HA groups on the ACE-R. Neither the ACE-R Memory subtest nor the BP total scores predicted performance on the psycholinguistic task for either the aMCI or the HA group. However, the ACE-R total score significantly predicted psycholinguistic task performance, with increased ACE-R performance predicting increased psycholinguistic task performance only for the HA group, not for the aMCI group. Conclusions: Results suggest a selective deterioration in language in aMCI, specifically a weakening of syntax-semantics integration in complex sentence processing, and a general independence of this language deficit and memory decline. Results cohere with previous assessments of the nature of difficulty in complex sentence formation in aMCI. We argue that clinical screening for prodromal AD can be strengthened by supplementary testing of language, as well as memory, and extended evaluation of strength of their relation. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01