Optogenetic Suppression of the Medial Septum Impairs Working Memory Maintenance

Autor/inn/en	Gemzik, Zachary M.; Donahue, Margaret M.; Griffin, Amy L.
Titel	Optogenetic Suppression of the Medial Septum Impairs Working Memory Maintenance
Quelle	In: Learning & Memory, 28 (2021) 10, S.361-370 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.053348.120
Schlagwörter	Short Term Memory; Spatial Ability; Task Analysis; Cues; Brain Hemisphere Functions; Cognitive Processes; Accuracy; Animals; Decision Making; Diseases; Drug Therapy + Suchen Sie Ihr Suchwort? Kurzzeitgedächtnis; Räumliches Vorstellungsvermögen; Aufgabenanalyse; Stichwort; Cognitive process; Kognitiver Prozess; Animal; Tier; Tiere; Decision-making; Entscheidungsfindung; Disease; Krankheit
Abstract	Spatial working memory (SWM) is the ability to encode, maintain, and retrieve spatial information over a temporal gap, and relies on a network of structures including the medial septum (MS), which provides critical input to the hippocampus. Although the role of the MS in SWM is well-established, up until recently, we have been unable to use temporally precise circuit manipulation techniques to examine the specific role of the MS in SWM, particularly to distinguish between encoding, maintenance, and retrieval. Here, we test the hypothesis that the MS supports the maintenance of spatial information over a temporal gap using precisely timed optogenetic suppression delivered during specific portions of three different tasks, two of which rely on SWM and one that does not. In experiment 1, we found that MS optogenetic suppression impaired choice accuracy of a SWM dependent conditional discrimination task. Moreover, this deficit was only observed when MS suppression was delivered during the cue-sampling, but not the cue-retrieval, portion of the trial. There was also no deficit when MS neurons were optogenetically suppressed as rats performed a SWM-independent variant of the task. In experiment 2, we tested whether MS suppression affected choice accuracy on a delayed nonmatch to position (DNMP) task when suppression was limited to the sample, delay, and choice phases of the task. We found that MS suppression delivery during the delay phase of the DNMP task, but not during the sample or choice phases, impaired choice accuracy. Our results collectively suggest that the MS plays an important role in SWM by maintaining task-relevant information over a temporal delay. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01