Sweetness of Aspartame: Introducing Key Statistical Concepts in an Upper Division Bioanalytical Laboratory Project

Autor/inn/en	Williamson, J. Charles; Silverstein, Todd P.
Titel	Sweetness of Aspartame: Introducing Key Statistical Concepts in an Upper Division Bioanalytical Laboratory Project
Quelle	In: Journal of Chemical Education, 98 (2021) 4, S.1233-1241 (9 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Williamson, J. Charles) ORCID (Silverstein, Todd P.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
DOI	10.1021/acs.jchemed.0c01072
Schlagwörter	Chemistry; Science Experiments; Food; Regression (Statistics); Mathematical Concepts + Suchen Sie Ihr Suchwort? Chemie; Lebensmittel; Regression; Regressionsanalyse
Abstract	We have expanded Stein's "Sweetness of Aspartame" laboratory project (Stein, P. J. "J. Chem. Educ." 1997, 74, 1112, DOI: 10.1021/ed074p1112) to include extensive use of statistical testing. Students test the statistical significance of a nonzero intercept in a linear regression, bias in comparison to a true value, and statistical significance of the difference between replicate measurements of two different samples. They also estimate error stemming from the use of a calibration curve and explore the pitfalls in linearizing nonlinear data (e.g., the unweighted Lineweaver--Burk plot). Students use t-values and p-values to perform hypothesis testing; they review algebraic error propagation calculations and linear regression and are introduced to nonlinear regression. This laboratory project applies key measurements and statistical analyses often covered in analytical chemistry and instrumental analysis to a fascinating biochemical reaction, the sensation of sweetness. (As Provided).
Anmerkungen	Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01