Aldol Condensation Reaction Rate Demonstrates Steric and Electronic Substituent Effects in the Organic Chemistry Lab

Autor/inn/en	Berardi, Matthew D.; Gentile, Filippo; Kozik, Isabelle; Gregg, Timothy M.
Titel	Aldol Condensation Reaction Rate Demonstrates Steric and Electronic Substituent Effects in the Organic Chemistry Lab
Quelle	In: Journal of Chemical Education, 98 (2021) 5, S.1732-1735 (4 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Gentile, Filippo) ORCID (Gregg, Timothy M.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0021-9584
DOI	10.1021/acs.jchemed.0c00448
Schlagwörter	Science Instruction; Organic Chemistry; Introductory Courses; Laboratory Experiments; Teaching Methods; Inquiry; Student Attitudes; Learning Processes; Observation; Scoring Rubrics + Suchen Sie Ihr Suchwort? Teaching of science; Science education; Natural sciences Lessons; Naturwissenschaftlicher Unterricht; Organische Chemie; Einführungskurs; Laboratory work; Laborarbeit; Teaching method; Lehrmethode; Unterrichtsmethode; Schülerverhalten; Learning process; Lernprozess; Beobachtung; Scoring formulas; Auswertungsbogen
Abstract	Aldol chemistry is highlighted in many introductory organic chemistry laboratory experiments because it provides synthesis, mechanism, and experimental challenges for students. In the experiment described here, students synthesize dibenzalacetone derivatives by crossed aldol condensation, observe reaction rates using a semiquantitative rubric, and illustrate the connection between reactant structures and reaction rate through their knowledge of the reaction mechanism. By combining class data and working through a guided-inquiry questionnaire, students link reaction rates with nucleophile and electrophile characteristics of the reactant structures. Independent rate determination of the aldol addition step, using UV absorption, confirmed that student rate observations of the overall reaction are a valid approach to learning about structure-function effects. (As Provided).
Anmerkungen	Division of Chemical Education, Inc. and ACS Publications Division of the American Chemical Society. 1155 Sixteenth Street NW, Washington, DC 20036. Tel: 800-227-5558; Tel: 202-872-4600; e-mail: eic@jce.acs.org; Web site: http://pubs.acs.org/jchemeduc
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01