Interaction of Blood Manganese Concentrations with "GSTT1" in Relation to Autism Spectrum Disorder in Jamaican Children

Autor/inn/en	Rahbar, Mohammad H.; Samms-Vaughan, Maureen; Saroukhani, Sepideh; Lee, MinJae; Zhang, Jing; Bressler, Jan; Hessabi, Manouchehr; Shakespeare-Pellington, Sydonnie; Grove, Megan L.; Loveland, Katherine A.
Titel	Interaction of Blood Manganese Concentrations with "GSTT1" in Relation to Autism Spectrum Disorder in Jamaican Children
Quelle	In: Journal of Autism and Developmental Disorders, 51 (2021) 6, S.1953-1965 (13 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Rahbar, Mohammad H.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-020-04677-z
Schlagwörter	Physiology; Autism; Pervasive Developmental Disorders; Foreign Countries; Socioeconomic Status; Interaction; Genetics; Jamaica + Suchen Sie Ihr Suchwort? Physiologie; Autismus; Ausland; Socio-economic status; Sozioökonomischer Status; Interaktion; Humangenetik
Abstract	Using data from 266 age- and sex-matched pairs of Jamaican children with autism spectrum disorder (ASD) and typically developing (TD) controls (2-8 years), we investigated whether glutathione S-transferase theta 1 ("GSTT1") modifies the association between blood manganese concentrations (BMC) and ASD. After adjusting conditional logistic regression models for socioeconomic status and the interaction between "GSTT1" and "GSTP1" (glutathione S-transferase pi 1), using a recessive genetic model for "GSTT1" and either a co-dominant or dominant model for "GSTP1," the interaction between "GSTT1" and BMC was significant (P = 0.02, P = 0.01, respectively). Compared to controls, ASD cases with "GSTT1"-DD genotype had 4.33 and 4.34 times higher odds of BMC > 12 vs. [less than or equal to] 8.3 µg/L, respectively. Replication in other populations is warranted. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01