Selective Enhancement of Fear Learning and Resistance to Extinction in a Mouse Model of Acute Early Life Trauma

Autor/inn/en	Sneddon, Elizabeth A.; Riddle, Collin A.; Schuh, Kristen M.; Quinn, Jennifer J.; Radke, Anna K.
Titel	Selective Enhancement of Fear Learning and Resistance to Extinction in a Mouse Model of Acute Early Life Trauma
Quelle	In: Learning & Memory, 28 (2021) 1, S.12-16 (5 Seiten) PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Sneddon, Elizabeth A.) ORCID (Quinn, Jennifer J.) ORCID (Radke, Anna K.)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.052373.120
Schlagwörter	Fear; Trauma; Animals; Stress Variables; Animal Behavior; Learning Processes; Novelty (Stimulus Dimension); Brain Hemisphere Functions + Suchen Sie Ihr Suchwort? Furcht; Animal; Tier; Tiere; Tierverhalten; Learning process; Lernprozess
Abstract	Early life stress (ELS) experiences can cause changes in cognitive and affective functioning. This study examined the persistent effects of a single traumatic event in infancy on several adult behavioral outcomes in male and female C57BL/6J mice. Mice received 15 footshocks in infancy and were tested for stress-enhanced fear learning, extinction learning, discrimination and reversal learning, and novel object recognition. Infant trauma potentiated fear learning in adulthood and produced resistance to extinction but did not influence other behaviors, suggesting restricted effects of infant trauma on behaviors reliant on cortico-amygdala circuitry. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01