A Review of Methods for Comparing Treatments Evaluated in Studies That Form Disconnected Networks of Evidence

Autor/inn/en	Stevens, John W.; Fletcher, Christine; Downey, Gerald; Sutton, Anthea
Titel	A Review of Methods for Comparing Treatments Evaluated in Studies That Form Disconnected Networks of Evidence
Quelle	In: Research Synthesis Methods, 9 (2018) 2, S.148-162 (15 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Stevens, John W.) ORCID (Sutton, Anthea)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1759-2879
DOI	10.1002/jrsm.1278
Schlagwörter	Meta Analysis; Network Analysis; Comparative Analysis; Outcomes of Treatment; Medical Research; Sampling; Evidence; Drug Therapy + Suchen Sie Ihr Suchwort? Meta-analysis; Metaanalyse; Netzplantechnik; Evidenz
Abstract	A network meta-analysis allows a simultaneous comparison between treatments evaluated in randomised controlled trials that share at least one treatment with at least one other study. Estimates of treatment effects may be required for treatments across disconnected networks of evidence, which requires a different statistical approach and modelling assumptions to account for imbalances in prognostic variables and treatment effect modifiers between studies. In this paper, we review and discuss methods for comparing treatments evaluated in studies that form disconnected networks of evidence. Several methods have been proposed but assessing which are appropriate often depends on the clinical context as well as the availability of data. Most methods account for sampling variation but do not always account for others sources of uncertainty. We suggest that further research is required to assess the properties of methods and the use of approaches that allow the incorporation of external information to reflect parameter and structural uncertainty. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01