Challenges of Identifying Unpublished Data from Clinical Trials: Getting the Best out of Clinical Trials Registers and Other Novel Sources

Autor/inn/en	Isojarvi, Jaana; Wood, Hannah; Lefebvre, Carol; Glanville, Julie
Titel	Challenges of Identifying Unpublished Data from Clinical Trials: Getting the Best out of Clinical Trials Registers and Other Novel Sources
Quelle	In: Research Synthesis Methods, 9 (2018) 4, S.561-578 (18 Seiten)Infoseite zur Zeitschrift PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Isojarvi, Jaana) ORCID (Wood, Hannah) ORCID (Glanville, Julie)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1759-2879
DOI	10.1002/jrsm.1294
Schlagwörter	Medical Research; Outcomes of Treatment; Intervention; Health Services; Research Reports; Evidence; Web Sites; Information Sources; Public Agencies; Manufacturing; Drug Therapy; Search Strategies; Online Searching; Barriers; Documentation; Information Scientists + Suchen Sie Ihr Suchwort? Health service; Gesundheitsdienst; Gesundheitswesen; Research report; Forschungsbericht; Evidenz; Web-Design; Information source; Informationsquelle; Öffentliche Einrichtung; Herstellung; Suchstrategie; Online-Recherche; Dokumentation; Informationswissenschaftler
Abstract	Clinical trial data are essential for assessments of the effectiveness of health care interventions. Information about ongoing or completed, but not yet formally published, trials has been more difficult to identify until the development of clinical trials registers and portals. This paper summarises research evidence on identifying sources of trial data, how and when to search those sources, and which future developments may enhance access to and retrieval of unpublished trial evidence. We conducted a literature search for relevant studies and provide a narrative review of the evidence from these studies. Clinical trial data can be found in resources including clinical trials registers, regulatory agency sources, health technology assessment websites and manufacturers' websites, and submissions for regulatory approval. The challenges of searching these resources are described. Trials registers are relatively unsophisticated in terms of their search interfaces, and searchers need to adapt to each individual register. There is overlap across registers, but little research on the degree and nature of overlap and how best to search. Despite these challenges, trials registers and other resources can be rich sources of additional unique trial data, which may not be available from journal reports. New initiatives, such as OpenTrials, aim to consolidate and link all structured data and documentation related to clinical trials. No single resource gives access to all trials, and multiple registers should be searched as sensitively as possible. Searching is challenging and should be adequately resourced. Information specialists should monitor new developments which may reduce the challenges over the coming years. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01