Postsynaptic Effects of "Aplysia" Cysteine-Rich Neurotrophic Factor in the Induction of Activity-Dependent Long-Term Facilitation in "Aplysia Californica"

Autor/inn/en	Alexandrescu, Anamaria; Carew, Thomas J.
Titel	Postsynaptic Effects of "Aplysia" Cysteine-Rich Neurotrophic Factor in the Induction of Activity-Dependent Long-Term Facilitation in "Aplysia Californica"
Quelle	In: Learning & Memory, 27 (2020) 4, S.124-129 PDF als Volltext Verfügbarkeit
Zusatzinformation	ORCID (Alexandrescu, Anamaria)
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.051011.119
Schlagwörter	Brain Hemisphere Functions; Memory; Spatial Ability; Sensory Integration; Training; Biochemistry; Genetics; Animals + Suchen Sie Ihr Suchwort? Gedächtnis; Räumliches Vorstellungsvermögen; Sensorische Integration; Ausbildung; Biochemie; Humangenetik; Animal; Tier; Tiere
Abstract	The spatial and temporal coordination of growth factor signaling is critical for both presynaptic and postsynaptic plasticity underlying long-term memory formation. We investigated the spatiotemporal dynamics of "Aplysia" cysteine-rich neurotrophic factor (ApCRNF) signaling during the induction of activity-dependent long-term facilitation (AD-LTF) at sensory-to-motor neuron synapses that mediate defensive reflexes in "Aplysia." We found that ApCRNF signaling is required for the induction of AD-LTF, and for training-induced early protein kinase activation and late forms of gene expression, exclusively in postsynaptic neurons. These results support the view that ApCRNF is critically involved in AD-LTF at least in part through postsynaptic mechanisms. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2024/1/01