Examining the Contribution of Histone Modification to Sex Differences in Learning and Memory

Autor/inn/en	Keiser, Ashley A.; Wood, Marcelo A.
Titel	Examining the Contribution of Histone Modification to Sex Differences in Learning and Memory
Quelle	In: Learning & Memory, 26 (2019) 9, S.318-331 (14 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.048850.118
Schlagwörter	Memory; Gender Differences; Molecular Structure; Genetics; Biochemistry; Females; Learning Processes + Suchen Sie Ihr Suchwort? Gedächtnis; Geschlechterkonflikt; Humangenetik; Biochemie; Weibliches Geschlecht; Learning process; Lernprozess
Abstract	The epigenome serves as a signal integration platform that encodes information from experience and environment that adds tremendous complexity to the regulation of transcription required for memory, beyond the directions encoded in the genome. To date, our understanding of how epigenetic mechanisms integrate information to regulate gene expression required for memory is primarily obtained from male derived data despite sex-specific life experiences and sex differences in consolidation and retrieval of memory, and in the molecular mechanisms that mediate these processes. In this review, we examine the contribution of chromatin modification to learning and memory in both sexes. We provide examples of how exposure to a number of internal and external factors influence the epigenome in sex-similar and sex-specific ways that may ultimately impact transcription required for memory processes. We also pose a number of key open questions and identify areas requiring further investigation as we seek to understand how histone modifying mechanisms shape memory in females. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01