Initially Intact Neural Responses to Pain in Autism Are Diminished during Sustained Pain

Autor/inn/en	Failla, Michelle D.; Moana-Filho, Estephan J.; Essick, Greg K.; Baranek, Grace T.; Rogers, Baxter P.; Cascio, Carissa J.
Titel	Initially Intact Neural Responses to Pain in Autism Are Diminished during Sustained Pain
Quelle	In: Autism: The International Journal of Research and Practice, 22 (2018) 6, S.669-683 (15 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1362-3613
DOI	10.1177/1362361317696043
Schlagwörter	Autism; Pervasive Developmental Disorders; Brain Hemisphere Functions; Responses; Pain; Diagnostic Tests; Adults; Coping; Injuries; Self Destructive Behavior; Observation; Likert Scales; Stimuli; Statistical Analysis; North Carolina; Autism Diagnostic Observation Schedule + Suchen Sie Ihr Suchwort? Autismus; Schmerz; Diagnostic test; Diagnostischer Test; Bewältigung; Self destrucive behaviour; Selbstzerstörung; Beobachtung; Likert-Skala; Anreizsystem; Statistische Analyse
Abstract	Pain assessments typically depend on self-report of the pain experience. Yet, in individuals with autism spectrum disorders, this can be an unreliable due to communication difficulties. Importantly, observations of behavioral hypo- and hyperresponsivity to pain suggest altered pain sensitivity in autism spectrum disorder. Neuroimaging may provide insight into mechanisms underlying pain behaviors. The neural pain signature reliably responds to painful stimulation and is modulated by other outside regions, affecting the pain experience. In this first functional magnetic resonance imaging study of pain in autism spectrum disorder, we investigated neural responses to pain in 15 adults with autism spectrum disorder relative to a typical comparison group (n = 16). We explored temporal and spatial properties of the neural pain signature and its modulators during sustained heat pain. The two groups had indistinguishable pain ratings and neural pain signature responses during acute pain; yet, we observed strikingly reduced neural pain signature response in autism spectrum disorder during sustained pain and after stimulus offset. The posterior cingulate cortex, a neural pain signature modulating region, mirrored this late signal reduction in autism spectrum disorder. Intact early responses, followed by diminished late responses to sustained pain, may reflect altered pain coping or evaluation in autism spectrum disorder. Evidence of a dichotomous neural response to initial versus protracted pain may clarify the coexistence of both hypo- and hyperresponsiveness to pain in autism spectrum disorder. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01