Evaluation of Linguistic Markers of Word-Finding Difficulty and Cognition in Parkinson's Disease

Autor/inn/en	Smith, Kara M.; Ash, Sharon; Xie, Sharon X.; Grossman, Murray
Titel	Evaluation of Linguistic Markers of Word-Finding Difficulty and Cognition in Parkinson's Disease
Quelle	In: Journal of Speech, Language, and Hearing Research, 61 (2018) 7, S.1691-1699 (9 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1092-4388
DOI	10.1044/2018_JSLHR-L-17-0304
Schlagwörter	Language Processing; Diseases; Questionnaires; Patients; Correlation; Scores; Symptoms (Individual Disorders); Vocabulary; Computer Software; Dementia; Older Adults; Audio Equipment; Comparative Analysis; Regression (Statistics); Naming; Pictorial Stimuli; Severity (of Disability); Speech Impairments; Language Impairments; Control Groups; Cognitive Ability + Suchen Sie Ihr Suchwort? Sprachverarbeitung; Disease; Krankheit; Fragebogen; Patient; Korrelation; Psychiatrische Symptomatik; Wortschatz; Demenz; Älterer Erwachsener; Audio-CD; Regression; Regressionsanalyse; Fantasieanregung; Schweregrad; Speech impairment; Speech handicap; Speech handicaps; Language handicps; Language impairments; Sprachbehinderung; Speech disorder; Speech disorders; Speech disabilities; Speech disability; Speech impairments; Language handicaps; Denkfähigkeit
Abstract	Purpose: Early cognitive symptoms such as word-finding difficulty (WFD) in daily conversation are common in Parkinson's disease (PD), but studies have been limited by a lack of feasible, quantitative measures. Linguistic analysis, focused on pauses in speech, may yield markers of impairment of cognition and communication in PD. The objective of this study was to evaluate the relationship of linguistic markers in semistructured speech to WFD symptoms and cognitive function in PD. Method: Speech recordings of description of the Cookie Theft picture in 53 patients with PD without dementia and 23 elderly controls were analyzed with Praat software. Montreal Cognitive Assessment (MoCA; Nasreddine et al., 2005), category naming fluency, and confrontation naming tests were administered. Questionnaires rating WFD symptoms and cognitive instrumental activities of daily living were completed. We determined the relationships between (a) pause length and location, (b) MoCA score, and (c) WFD symptoms, using Pearson's correlations and multivariate regression models. Results: Compared with controls, patients with PD had more pauses within utterances as well as fewer words per minute and a lower percentage of well-formed sentences. Pauses within utterances differed significantly between PD--mild cognitive impairment and normal cognition (p < 0.001). Words per minute and percentage of well-formed sentences were predictive of MoCA in multivariate regression models. Pauses before verbs were associated with patient-reported severity of WFD symptoms (p = .006). Conclusions: Linguistic markers including pauses within utterances distinguish patients with PD with mild cognitive symptoms from elderly controls. These markers are associated with global cognitive function before the onset of dementia. Pauses before verbs and grammatical markers may index early cognitive symptoms such as WFD that may interfere with functional communication. (As Provided).
Anmerkungen	American Speech-Language-Hearing Association. 2200 Research Blvd #250, Rockville, MD 20850. Tel: 301-296-5700; Fax: 301-296-8580; e-mail: slhr@asha.org; Web site: http://jslhr.pubs.asha.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01