Juvenile Female Rats, but Not Male Rats, Show Renewal, Reinstatement, and Spontaneous Recovery Following Extinction of Conditioned Fear

Autor/inn/en	Park, Chun Hui J.; Ganella, Despina E.; Kim, Jee Hyun
Titel	Juvenile Female Rats, but Not Male Rats, Show Renewal, Reinstatement, and Spontaneous Recovery Following Extinction of Conditioned Fear
Quelle	In: Learning & Memory, 24 (2017) 12, S.630-636 (7 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.045831.117
Schlagwörter	Animals; Anxiety Disorders; Gender Differences; Fear; Behavior; Conditioning; Learning Processes; Statistical Analysis; Foreign Countries; Australia + Suchen Sie Ihr Suchwort? Animal; Tier; Tiere; Geschlechterkonflikt; Furcht; Learning process; Lernprozess; Statistische Analyse; Ausland; Australien
Abstract	Anxiety disorders emerge early, and girls are significantly more likely to develop anxiety compared to boys. However, sex differences in fear during development are poorly understood. Therefore, we investigated juvenile male and female rats in the relapse behaviors following extinction of conditioned fear. In all experiments, 18-d-old rats first received three white-noise-footshock pairings on day 1. On day 2, extinction involved 60 white-noise alone trials. In experiment 1, we examined renewal by testing the rats in either the same or different context as extinction on day 3. Male rats did not show renewal, however, female rats showed renewal. Experiment 2 investigated reinstatement by giving rats either a mild reminder footshock or context exposure on day 3. When tested the next day, male rats did not show reinstatement, whereas female rats showed reinstatement. Experiment 3 investigated spontaneous recovery by testing the rats either 1 or 5 d following extinction. Male rats did not show any spontaneous recovery whereas female rats did. Taken together, fear regulation appear to be different in males versus females from early in development, which may explain why girls are more prone to suffer from anxiety disorders compared to boys. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01