A Comparison of Behavioral and Pharmacological Interventions to Attenuate Reactivated Fear Memories

Autor/inn/en	Monti, Roque I. Ferrer; Alfei, Joaquin M.; Mugnaini, Matias; Bueno, Adrian M.; Beckers, Tom; Urcelay, Gonzalo P.; Molina, Victor A.
Titel	A Comparison of Behavioral and Pharmacological Interventions to Attenuate Reactivated Fear Memories
Quelle	In: Learning & Memory, 24 (2017) 8, S.369-374 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.045385.117
Schlagwörter	Behavior; Fear; Memory; Drug Therapy; Intervention; Animals; Learning Processes; Training; Outcomes of Treatment + Suchen Sie Ihr Suchwort? Furcht; Gedächtnis; Animal; Tier; Tiere; Learning process; Lernprozess; Ausbildung
Abstract	Two experiments using rats in a contextual fear memory preparation compared two approaches to reduce conditioned fear: (1) pharmacological reconsolidation blockade and (2) reactivation-plus-extinction training. In Experiment 1, we explored different combinations of reactivation-plus-extinction parameters to reduce conditioned fear and attenuate reacquisition. In Experiment 2, memory reactivation was followed by extinction training or administration of midazolam (MDZ) (vs. vehicle) to reduce conditioned fear and attenuate spontaneous recovery. We found both treatments to be equally effective in both experiments. This study suggests that parameters leading to memory destabilization during reactivation are critical to observe long-lasting effects of MDZ or reactivation plus extinction. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01