AMPA Receptors Control Fear Extinction through an Arc-Dependent Mechanism

Autor/inn/en	Trent, Simon; Barnes, Philip; Hall, Jeremy; Thomas, Kerrie L.
Titel	AMPA Receptors Control Fear Extinction through an Arc-Dependent Mechanism
Quelle	In: Learning & Memory, 24 (2017) 8, S.375-380 (6 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.045013.117
Schlagwörter	Fear; Memory; Learning Processes; Brain + Suchen Sie Ihr Suchwort? Furcht; Gedächtnis; Learning process; Lernprozess; Gehirn
Abstract	Activity-regulated cytoskeleton-associated protein (Arc) supports fear memory through synaptic plasticity events requiring actin cytoskeleton rearrangements. We have previously shown that reducing hippocampal Arc levels through antisense knockdown leads to the premature extinction of contextual fear. Here we show that the AMPA receptor antagonist CNQX elevates hippocampal Arc levels during extinction and blocks extinction that can be rescued by reducing Arc. Increasing Arc levels with CNQX also overcomes the actin-destabilizing properties of cytochalasin D and promotes extinction. Therefore, extinction is dependent on AMPA-mediated reductions of Arc via a mechanism consistent with a role for Arc in stabilizing the actin cytoskeleton to constrain extinction. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01