A Causal and Mediation Analysis of the Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD)

Autor/inn/en	Sokolova, Elena; Oerlemans, Anoek M.; Rommelse, Nanda N.; Groot, Perry; Hartman, Catharina A.; Glennon, Jeffrey C.; Claassen, Tom; Heskes, Tom; Buitelaar, Jan K.
Titel	A Causal and Mediation Analysis of the Comorbidity between Attention Deficit Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD)
Quelle	In: Journal of Autism and Developmental Disorders, 47 (2017) 6, S.1595-1604 (10 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-017-3083-7
Schlagwörter	Autism; Pervasive Developmental Disorders; Causal Models; Mediation Theory; Attention Deficit Hyperactivity Disorder; Comorbidity; Symptoms (Individual Disorders); Children; Siblings; Structural Equation Models; Self Control; Behavior Problems; Repetition; Attention Control; Comprehension; Verbal Ability; Intelligence Quotient; Physiology; Interpersonal Competence + Suchen Sie Ihr Suchwort? Autismus; Kausalanalyse; Mediationsverfahren; Psychiatrische Symptomatik; Child; Kind; Kinder; Sibling; Geschwister; Selbstbeherrschung; Wiederholung; Aufmerksamkeitstest; Verstehen; Verständnis; Mündliche Leistung; Intelligenzquotient; Physiologie; Interpersonale Kompetenz
Abstract	Autism spectrum disorder (ASD) and Attention-deficit/hyperactivity disorder (ADHD) are often comorbid. The purpose of this study is to explore the relationships between ASD and ADHD symptoms by applying causal modeling. We used a large phenotypic data set of 417 children with ASD and/or ADHD, 562 affected and unaffected siblings, and 414 controls, to infer a structural equation model using a causal discovery algorithm. Three distinct pathways between ASD and ADHD were identified: (1) from impulsivity to difficulties with understanding social information, (2) from hyperactivity to stereotypic, repetitive behavior, (3) a pairwise pathway between inattention, difficulties with understanding social information, and verbal IQ. These findings may inform future studies on understanding the pathophysiological mechanisms behind the overlap between ASD and ADHD. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01