Primary Auditory Cortex Regulates Threat Memory Specificity

Autor/inn/en	Wigestrand, Mattis B.; Schiff, Hillary C.; Fyhn, Marianne; LeDoux, Joseph E.; Sears, Robert M.
Titel	Primary Auditory Cortex Regulates Threat Memory Specificity
Quelle	In: Learning & Memory, 24 (2017) 1, S.55-58 (4 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.044362.116
Schlagwörter	Memory; Brain Hemisphere Functions; Stimuli; Generalization; Auditory Perception; Animals; Prediction; Learning Processes; Anxiety Disorders; Auditory Discrimination; Drug Therapy + Suchen Sie Ihr Suchwort? Gedächtnis; Anreizsystem; Auditive Wahrnehmung; Akustische Wahrnehmung; Akustik; Animal; Tier; Tiere; Vorhersage; Learning process; Lernprozess
Abstract	Distinguishing threatening from nonthreatening stimuli is essential for survival and stimulus generalization is a hallmark of anxiety disorders. While auditory threat learning produces long-lasting plasticity in primary auditory cortex (Au1), it is not clear whether such Au1 plasticity regulates memory specificity or generalization. We used muscimol infusions in rats to show that discriminatory threat learning requires Au1 activity specifically during memory acquisition and retrieval, but not during consolidation. Memory specificity was similarly disrupted by infusion of PKM? inhibitor peptide (ZIP) during memory storage. Our findings show that Au1 is required at critical memory phases and suggest that Au1 plasticity enables stimulus discrimination. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://learnmem.cshlp.org
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01