Brief Report: Autism Symptoms in Infants with Fragile X Syndrome

Autor/inn/en	Roberts, Jane E.; Tonnsen, Bridgette L.; McCary, Lindsay M.; Caravella, Kelly E.; Shinkareva, Svetlana V.
Titel	Brief Report: Autism Symptoms in Infants with Fragile X Syndrome
Quelle	In: Journal of Autism and Developmental Disorders, 46 (2016) 12, S.3830-3837 (8 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	0162-3257
DOI	10.1007/s10803-016-2903-5
Schlagwörter	Genetic Disorders; Intellectual Disability; Congenital Impairments; Infants; Autism; Pervasive Developmental Disorders; Comparative Analysis; Genetics; Siblings; Measures (Individuals); Observation + Suchen Sie Ihr Suchwort? Intellect; Disability; Disabilities; Verstand; Behinderung; Infant; Toddler; Toddlers; Kleinkind; Autismus; Humangenetik; Sibling; Geschwister; Messdaten; Beobachtung
Abstract	Fragile X syndrome (FXS) is the most common known genetic cause of autism spectrum disorder (ASD). Although 50-75% of children with FXS meet ASD criteria, no studies have compared ASD symptoms in infants with FXS versus other high risk groups, such as siblings of children with ASD (ASIBs). Using the Autism Observation Scale for Infants, our findings indicate that 53% of 12-month infants with FXS fall in the "at risk" category compared to 17 and 6% for age-matched ASIBs and controls, respectively. Elevated atypical motor behaviors were associated with elevated risk for FXS. Cross-syndrome comparisons are essential to understanding the heterogeneity of ASD and identifying candidate markers that will facilitate differential diagnosis of ASD in genetic disorders such as FXS. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01