Synapsin Is Required to "Boost" Memory Strength for Highly Salient Events

Autor/inn/en	Kleber, Jörg; Chen, Yi-Chun; Michels, Birgit; Saumweber, Timo; Schleyer, Michael; Kähne, Thilo; Buchner, Erich; Gerber, Bertram
Titel	Synapsin Is Required to "Boost" Memory Strength for Highly Salient Events
Quelle	In: Learning & Memory, 23 (2016) 1, S.9-20 (12 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.039685.115
Schlagwörter	Associative Learning; Genetics; Scores; Short Term Memory; Entomology; Biochemistry; Psychomotor Skills; Rewards; Animals; Olfactory Perception; Learning Processes + Suchen Sie Ihr Suchwort? Humangenetik; Kurzzeitgedächtnis; Entomologie; Biochemie; Psychomotorische Aktivität; Reward; Belohnung; Animal; Tier; Tiere; Learning process; Lernprozess
Abstract	Synapsin is an evolutionarily conserved presynaptic phosphoprotein. It is encoded by only one gene in the "Drosophila" genome and is expressed throughout the nervous system. It regulates the balance between reserve and releasable vesicles, is required to maintain transmission upon heavy demand, and is essential for proper memory function at the behavioral level. Task-relevant sensorimotor functions, however, remain intact in the absence of Synapsin. Using an odor-sugar reward associative learning paradigm in larval "Drosophila", we show that memory scores in mutants lacking Synapsin ("syn"[superscript 97]) are lower than in wild-type animals only when more salient, higher concentrations of odor or of the sugar reward are used. Furthermore, we show that Synapsin is selectively required for larval short-term memory. Thus, without Synapsin "Drosophila" larvae can learn and remember, but Synapsin is required to form memories that match in strength to event salience--in particular to a high saliency of odors, of rewards, or the salient recency of an event. We further show that the residual memory scores upon a lack of Synapsin are not further decreased by an additional lack of the Sap47 protein. In combination with mass spectrometry data showing an up-regulated phosphorylation of Synapsin in the larval nervous system upon a lack of Sap47, this is suggestive of a functional interdependence of Synapsin and Sap47. (As Provided).
Anmerkungen	Cold Spring Harbor Laboratory Press. 500 Sunnyside Boulevard, Woodbury, NY 11797-2924. Tel: 800-843-4388; Tel: 516-367-8800; Fax: 516-422-4097; e-mail: cshpres@cshl.edu; Web site: http://www.learnmem.org/
Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01