Cholinergic Manipulations Bidirectionally Regulate Object Memory Destabilization

Autor/inn/en	Stiver, Mikaela L.; Jacklin, Derek L.; Mitchnick, Krista A.; Vicic, Nevena; Carlin, Justine; O'Hara, Matthew; Winters, Boyer D.
Titel	Cholinergic Manipulations Bidirectionally Regulate Object Memory Destabilization
Quelle	In: Learning & Memory, 22 (2015) 4, S.203-214 (12 Seiten) PDF als Volltext Verfügbarkeit
Sprache	englisch
Dokumenttyp	gedruckt; online; Zeitschriftenaufsatz
ISSN	1072-0502
DOI	10.1101/lm.037713.114
Schlagwörter	Memory; Animals; Recognition (Psychology); Mnemonics; Biochemistry; Brain Hemisphere Functions; Learning Processes; Novelty (Stimulus Dimension); Drug Use; Cognitive Ability; Long Term Memory + Suchen Sie Ihr Suchwort? Gedächtnis; Animal; Tier; Tiere; Recognition; Wiedererkennen; Mnemotechnik; Biochemie; Learning process; Lernprozess; Drug consumption; Substance abuse; Drogenkonsum; Denkfähigkeit; Langzeitgedächtnis
Abstract	Consolidated memories can become destabilized and open to modification upon retrieval. Destabilization is most reliably prompted when novel information is present during memory reactivation. We hypothesized that the neurotransmitter acetylcholine (ACh) plays an important role in novelty-induced memory destabilization because of its established involvement in new learning. Accordingly, we investigated the effects of cholinergic manipulations in rats using an object recognition paradigm that requires reactivation novelty to destabilize object memories. The muscarinic receptor antagonist scopolamine, systemically or infused directly into the perirhinal cortex, blocked this novelty-induced memory destabilization. Conversely, systemic oxotremorine or carbachol, muscarinic receptor agonists, administered systemically or intraperirhinally, respectively, mimicked the destabilizing effect of novel information during reactivation. These bidirectional effects suggest a crucial influence of ACh on memory destabilization and the updating functions of reconsolidation. This is a hitherto unappreciated mnemonic role for ACh with implications for its potential involvement in cognitive flexibility and the dynamic process of long-term memory storage. (As Provided).
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Erfasst von	ERIC (Education Resources Information Center), Washington, DC
Update	2020/1/01